The emerging role of KDM5A in human cancer

Table 1 The roles of KDM5A in homeostasis

Model (cells/tissues/species)	Mechanism	Functions	References
Preadipocytes	C/EBPβ blocks Wnt/β-catenin activity in a demethylase-dependent fashion and represses Wnt6 transcription	Promoting preadipocyte differentiation	[75]
Reprogramming-resistant fibroblast	KDM5A transcriptionally inhibits OCT4 expression	Inhibiting reprogramming efficiency	[71]
Mouse embryonic stem cells	KDM5A transcriptionally inhibits cell cycle genes	Repressing cell differentiation	[74,75,76]
Heart	KDM5A interacts with CLOCK-BMAL1 to bind to the Per2 promoter, increasing histone acetylation and enhancing transcription in a demethylase-independent fashion	Activating CLOCK-BMAL1 and affecting the circadian clock	[77]
Natural killer cells	KDM5A mediates NK cell activation through interacting with p50 to inhibit SOCS1	Activating NK cells	[79]
IMR-90 cells	KDM5A contributes to retinoblastoma-mediated gene silencing	Mediating cellular senescence	[78]
Drosophila	KDM5 regulates immune control and gut microbiota maintenance	Regulating social behavior	[81]

ISSN: 1756-8722