|
Acute myeloid leukemia
|
KDM5A forms fused gene with NUP98 and maintains expression of the Hoxa gene cluster via specifically binding their promoters
|
Blocking genetic program required for normal cellular differentiation
|
[5, 51, 90, 91]
|
|
Breast cancer
|
KDM5A transcriptionally inhibits expression of p16, p27, and Bak-1, and induces ITGB1 expression
|
Promoting cancer proliferation, drug tolerance, and metastasis
|
[5, 9, 12, 23, 29, 92,93,94]
|
|
Prostate cancer
|
KDM5A decrease the levels of two tumor suppression and differentiation genes KLF4 and E-cadherin
|
Leading to malignancy of PCs
|
[95,96,97,98]
|
|
Glioblastoma
|
KDM5A promotes cell proliferation, self-renewal, and drug resistance of GBM by regulating Hoxa-9 and -10 and transcription factor FOXM; it promotes migration and invasion of glioma cells via downregulating ZEB1
|
Promoting proliferation, self-renewal, and drug resistance of GBM and inhibiting the migration and invasion of glioma cells
|
[4, 99, 100]
|
|
Lung cancer
|
KDM5A inhibiting the expression of p27 and TFPI2, and upregulating cyclin D1, and ITGB1; it promotes angiogenesis and EMT via Akt signaling
|
Facilitating proliferation, motility, migration, invasion, metastasis, and drug resistance of lung cancer
|
[13, 25, 101, 102]
|
|
Gastric cancer
|
KDM5A represses its target genes CDKIs (p16, p21, and p27); it transactivates VEGF and promotes gastric tumorigenesis
|
Promoting proliferation metastasis, and angiogenesis
|
[7, 8, 103, 104]
|
|
Hepatocellular carcinoma
|
KDM5A is negatively regulated by miR-21, and repressed cyclin-dependent kinase inhibitors (CDKIs)
|
Promoting proliferation and inducing senescence
|
[105, 106]
|
|
Renal cell carcinoma
|
KDM5A induces stem-like cancer cells and promote RCC in demethylase-dependent manner
|
Facilitating proliferation, metastasis and inducing stemness of cancer cells
|
[47, 107]
|
|
Pancreatic cancer
|
KDM5A transcriptionally inhibits IGF2BP2 expression and MPC-1
|
Promoting aerobic glycolysis and cell proliferation
|
[108, 109]
|
|
Melanoma
|
KDM5A work as a tumor suppressor gene
|
Improving the response of melanoma to PD-L1 antibody
|
[110,111,112]
|
|
Ovarian cancer
|
KDM5A promotes cancer progression in demethylase-dependent manner
|
Promoting proliferation EMT, and drug resistance
|
[6, 113]
|
