|
Signaling
|
RAS signaling
|
GLUT, HK, PFK
|
UPS, MFS
|
Poor prognosis
|
[33, 34]
|
|
PI3K-AKT signaling
| |
LMS, EWS
|
Poor prognosis
|
[35, 36]
|
|
miR-181b
|
STLMS, ULMS
|
RFS
|
[8]
|
|
MDM2 amplification
|
DDLPS
|
Poor prognosis
| |
|
GFR signaling
|
IGFR1 overexpression
|
STLMS, EWS, MLS, ARMS, SS
|
Poor RFS/DSS
|
[8, 37, 38]
|
|
Her4/Erbb4
|
OS, EWS
|
Poor prognosis
|
[38]
|
|
Serum bFGF, VEGF
|
STS
|
Poor prognosis
|
[39]
|
|
JUN signaling
| |
DDLPS
|
Poor prognosis
|
[8]
|
|
HIPPO pathway
|
Nuclear YAP/TAZ, VGLL3
|
UPS, MFS, MLS, RMS
|
Poor prognosis
|
[40,41,42,43,44,45]
|
|
WNT pathway
|
Nuclear β-catenin/LEF1; MEG3 (lncRNA) downregulation
|
EWS, OS
|
Poor prognosis
|
[46, 47]
|
|
Cell cycle/death
|
Cell cycle
|
CINSARC—67 genes
|
STS
|
Poor prognosis
|
[48]
|
|
TP53, RB1, CDKN2A deficiency
|
LMS, UPS, MFS
|
Poor prognosis
|
[8, 49,50,51]
|
|
TP53, IGAR, GLUT
|
LMS, UPS, MFS, EWS
|
Poor prognosis
|
|
CDCA2, KIF14, IGBP7
|
SS
|
Metastasis
|
[52]
|
|
CDK4 amplification
|
DDLPS
|
Poor prognosis
|
[8]
|
|
DNA replication
|
TOP2A
|
MPNST
|
Poor prognosis
|
[8]
|
|
RRM1
|
OS, EWS
|
Good prognosis
|
[8]
|
|
ATRX deletion
|
DDLPS
|
Poor prognosis
|
[8]
|
|
Transcriptional regulation
|
DNA hypermethylation,
|
DDLPS, STLMS
|
poor RFS/DSS
|
[8]
|
|
HMGA2 amplification
|
DDLPS
|
Poor prognosis
|
[8]
|
|
Energetic pathways
|
Glycolysis
|
GLUT, ENO1, TPI1, PKG1, LDHC, lactate, pyruvate
|
STS
|
Poor prognosis
|
[20, 53, 54]
|
|
FBP2 loss
|
LPS, LMS, FS, UPS
|
Poor DSS
|
[55]
|
|
Serum LDH
|
ULMS, EWS
|
Poor prognosis
|
[39, 51]
|
|
PKM1/2 isoenzymes
|
OS
|
Poor prognosis
|
[56]
|
|
Pentose and glucoronate interconversions
|
UGT
|
STS
|
Prognosis
|
[20]
|
|
Citrate cycle/OXPHOS
|
Downregulated metabolites
|
OS
|
Poor prognosis
|
[27]
|
|
Decreased ATP Synthase subunits
|
OS
|
Poor prognosis
|
[56]
|
|
SDH, FH mutations (succinate accumulation)
|
GIST
|
Poor prognosis
|
[57]
|
|
Others
|
AMPKa, CHK1, S6, ARID1A, RBM15, MSH6, AcetylTubulin
|
STS
|
Combined survival related signature
|
[58]
|
| |
Nucleotide metabolism
| |
STS
|
Poor prognosis
|
[57]
|
|
Amino acids
|
Alanine, aspartate, glutamate
|
GLS
|
OS, KS, EWS
|
High risk
|
[27, 59, 60, 56]
|
|
Arginine, ornithine
|
ASS1 deficiency, ODC
|
OS, MFS, KS
|
DSS, MFS
|
[27, 61, 62]
|
|
Proline
|
PYCR2
|
OS, KS
|
DSS, MFS
|
[27, 63]
|
|
Serine, glycine
|
PHGDH, PSAT1, PSPH, SHMT2, SLC1A5, MTHFD2, MTHFD1L
|
EWS
|
DSS, MFS
|
[60, 64]
|
|
Tryptophane
|
TDO2 (low)
|
EWS
|
DSS, MFS
|
[65]
|
|
5 methylthioadenosine
| |
OS
|
DSS, MFS
|
[27]
|
|
Redox, vitamins
|
Pantothenate metabolism
|
VNN1 (low)
|
FS
|
Poor prognosis
|
[66]
|
|
Redox metabolism
|
TXR, MIF1, GAL1, AcCoaBP
|
LMS (high), MFS (low)
|
Poor prognosis
|
[67]
|
|
Hypoxia
|
HIF1α, hypoxia gene signatures
|
EWS, OS, GIST, KS
|
Poor prognosis
|
[68,69,70,71,72]
|
